PDB Structure Viewer
Title: HUMAN 20S PROTEASOME COMPLEX WITH BORTEZOMIB AT 2.1 ANGSTROM
Experimental Method: X-RAY DIFFRACTION
Resolution: 2.10 Å
Ligands: 1PE, 6V1, BO2, CL, K, MG, YCM
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b
Viewer size: 800 x 600
Chain style: {'stick': {}}
Residue style: {'stick': {'colorscheme': 'cyanCarbon'}}
Generated: 2025-12-04 23:10:26
Script: binding_visualizer.py
Config file: binding_visualizer.yaml
Python version: 3.9.6
Platform: Darwin 25.1.0
User/Host: andreazedda@Andreas-MacBook-Pro.local
PDB Downloaded: 2025-12-04 23:10:23 UTC
Script SHA256: e89f1faf6ee9655ae203d31845ffb09454b5c20c559a51cccbf79de053770372
Config SHA256: 1ce6ee74ccaabab4864ef72cbd4d9e668cbefe7d8b96aedb8f8dc233ed37f6eb
Instructions: Drag to rotate, scroll to zoom, double-click to center. Hover over atoms for details.
Dependencies: py3Dmol 2.4.0, requests 2.32.3, pyyaml 6.0.2
Git commit: 4c5e395
Show YAML Config
pdb_id: 5LF3
viewer:
width: 800
height: 600
visualization:
chain_style:
stick: {}
residue_style:
stick:
colorscheme: cyanCarbon
ligand: BOR
generate_pdf: false
pdf_options:
include_structure_image: true
image_width: 800
image_height: 600
cleanup_aux_files: false
binding_site_detection:
enabled: true
cutoff_angstrom: 5.0
mutations:
- chain: K
resnum: 45
mutation: A45T
effect: resistance
- chain: K
resnum: 49
mutation: C49W
effect: unknown
therapies:
- name: Bortezomib
pdb_ligand: BOR
clinical_phase: Approved
mechanism: Proteasome inhibitor targeting the 26S proteasome
mm_relevance: High
resistance_mutations:
- A45T
- C49W
- name: Carfilzomib
pdb_ligand: '...'
clinical_phase: Approved
mm_relevance: High
resistance_mutations:
- '...'
pathways:
- name: Proteasome pathway
kegg_id: hsa03050
reactome_id: R-HSA-174084
literature:
- doi: 10.1126/science.aaf8993
pmid: '27493187'
title: The inhibition mechanism of human 20S proteasomes enables next-generation
inhibitor design.
| Chain | ResNum | Mutation | Effect |
|---|
| K | 45 | A45T | resistance |
| K | 49 | C49W | unknown |
| Name | Ligand | Phase | MM Relevance | Resistance Mutations |
|---|
| Bortezomib | BOR | Approved | High | A45T, C49W |
| Carfilzomib | ... | Approved | High | ... |
Visualization generated by
binding_visualizer.py using
py3Dmol.
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