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PDB Structure Viewer

PDB ID: 5LF3
Title: HUMAN 20S PROTEASOME COMPLEX WITH BORTEZOMIB AT 2.1 ANGSTROM
Experimental Method: X-RAY DIFFRACTION
Resolution: 2.10 Å
Ligands: 1PE, 6V1, BO2, CL, K, MG, YCM
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b
Viewer size: 800 x 600
Chain style: {'stick': {}}
Residue style: {'stick': {'colorscheme': 'cyanCarbon'}}
Generated: 2025-12-04 23:10:26
Script: binding_visualizer.py
Config file: binding_visualizer.yaml
Python version: 3.9.6
Platform: Darwin 25.1.0
User/Host: andreazedda@Andreas-MacBook-Pro.local
PDB Downloaded: 2025-12-04 23:10:23 UTC
Script SHA256: e89f1faf6ee9655ae203d31845ffb09454b5c20c559a51cccbf79de053770372
Config SHA256: 1ce6ee74ccaabab4864ef72cbd4d9e668cbefe7d8b96aedb8f8dc233ed37f6eb
Instructions: Drag to rotate, scroll to zoom, double-click to center. Hover over atoms for details.
Dependencies: py3Dmol 2.4.0, requests 2.32.3, pyyaml 6.0.2
Git commit: 4c5e395
Downloads: PDB file | YAML config
Show YAML Config
pdb_id: 5LF3
viewer:
  width: 800
  height: 600
visualization:
  chain_style:
    stick: {}
  residue_style:
    stick:
      colorscheme: cyanCarbon
ligand: BOR
generate_pdf: false
pdf_options:
  include_structure_image: true
  image_width: 800
  image_height: 600
  cleanup_aux_files: false
binding_site_detection:
  enabled: true
  cutoff_angstrom: 5.0
mutations:
- chain: K
  resnum: 45
  mutation: A45T
  effect: resistance
- chain: K
  resnum: 49
  mutation: C49W
  effect: unknown
therapies:
- name: Bortezomib
  pdb_ligand: BOR
  clinical_phase: Approved
  mechanism: Proteasome inhibitor targeting the 26S proteasome
  mm_relevance: High
  resistance_mutations:
  - A45T
  - C49W
- name: Carfilzomib
  pdb_ligand: '...'
  clinical_phase: Approved
  mm_relevance: High
  resistance_mutations:
  - '...'
pathways:
- name: Proteasome pathway
  kegg_id: hsa03050
  reactome_id: R-HSA-174084
literature:
- doi: 10.1126/science.aaf8993
  pmid: '27493187'
  title: The inhibition mechanism of human 20S proteasomes enables next-generation
    inhibitor design.
Citation: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
ChainResNumMutationEffect
K45A45Tresistance
K49C49Wunknown
NameLigandPhaseMM RelevanceResistance Mutations
BortezomibBORApprovedHighA45T, C49W
Carfilzomib...ApprovedHigh...
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