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PDB ID: 5LF3

Title: HUMAN 20S PROTEASOME COMPLEX WITH BORTEZOMIB AT 2.1 ANGSTROM

Experimental Method: X-RAY DIFFRACTION

Resolution: 2.10 Å

Ligands: 1PE, 6V1, BO2, CL, K, MG, YCM

Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b

Viewer size: 800 x 600

Chain style: {'stick': {}}

Residue style: {'stick': {'colorscheme': 'cyanCarbon'}}

Generated: 2025-12-04 23:10:26

Script: binding_visualizer.py

Config file: binding_visualizer.yaml

Python version: 3.9.6

Platform: Darwin 25.1.0

User/Host: andreazedda@Andreas-MacBook-Pro.local

PDB Downloaded: 2025-12-04 23:10:23 UTC

Script SHA256: e89f1faf6ee9655ae203d31845ffb09454b5c20c559a51cccbf79de053770372

Config SHA256: 1ce6ee74ccaabab4864ef72cbd4d9e668cbefe7d8b96aedb8f8dc233ed37f6eb

Instructions: Drag to rotate, scroll to zoom, double-click to center. Hover over atoms for details.

Dependencies: py3Dmol 2.4.0, requests 2.32.3, pyyaml 6.0.2

Git commit: 4c5e395

Downloads: PDB file | YAML config

Show YAML Config

pdb_id: 5LF3
viewer:
  width: 800
  height: 600
visualization:
  chain_style:
    stick: {}
  residue_style:
    stick:
      colorscheme: cyanCarbon
ligand: BOR
generate_pdf: false
pdf_options:
  include_structure_image: true
  image_width: 800
  image_height: 600
  cleanup_aux_files: false
binding_site_detection:
  enabled: true
  cutoff_angstrom: 5.0
mutations:
- chain: K
  resnum: 45
  mutation: A45T
  effect: resistance
- chain: K
  resnum: 49
  mutation: C49W
  effect: unknown
therapies:
- name: Bortezomib
  pdb_ligand: BOR
  clinical_phase: Approved
  mechanism: Proteasome inhibitor targeting the 26S proteasome
  mm_relevance: High
  resistance_mutations:
  - A45T
  - C49W
- name: Carfilzomib
  pdb_ligand: '...'
  clinical_phase: Approved
  mm_relevance: High
  resistance_mutations:
  - '...'
pathways:
- name: Proteasome pathway
  kegg_id: hsa03050
  reactome_id: R-HSA-174084
literature:
- doi: 10.1126/science.aaf8993
  pmid: '27493187'
  title: The inhibition mechanism of human 20S proteasomes enables next-generation
    inhibitor design.

Citation: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

Chain	ResNum	Mutation	Effect
K	45	A45T	resistance
K	49	C49W	unknown

Name	Ligand	Phase	MM Relevance	Resistance Mutations
Bortezomib	BOR	Approved	High	A45T, C49W
Carfilzomib	...	Approved	High	...

Proteasome pathway hsa03050 R-HSA-174084

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. 10.1126/science.aaf8993 27493187

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